The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Small interfering RNAs and microRNAs are generated from double-stranded RNA
precursors by the Dicer endonucleases, and function with Argonaute-family proteins to …

The generation of haploid gametes by meiosis is a highly conserved process for sexually
reproducing organisms that, in almost all cases, involves the extensive breakage of …

Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting
RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway …

RNAi is a widespread mechanism by which organisms regulate gene expression and
defend their genomes against viruses and transposable elements. Here we report the …

We have used genetic and microarray analysis to determine how ionizing radiation (IR)
induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces …

Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the
induction of cell cycle arrest and apoptosis by DNA damage. Insight into Chk2 has derived …

Gametes are highly specialized cell types produced by a complex differentiation process.
Production of viable oocytes requires a series of precise and coordinated molecular events …

Small repeat-associated siRNAs (rasiRNAs) mediate silencing of retrotransposons and the
Stellate locus. Mutations in the Drosophila rasiRNA pathway genes armitage and aubergine …

Production of functional eggs requires meiosis to be coordinated with developmental
signals. Oocytes arrest in prophase I to permit oocyte differentiation, and in most animals, a …