Visible-light-mediated modification and manipulation of biomacromolecules
Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …
have become crucial tools in chemical biology. They are extensively used not only to …
The role of mRNA m6A methylation in the nervous system
J Li, X Yang, Z Qi, Y Sang, Y Liu, B Xu, W Liu, Z Xu… - Cell & bioscience, 2019 - Springer
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA
regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery …
regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery …
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine
ZW Wang, JJ Pan, JF Hu, JQ Zhang, L Huang, Y Huang… - Cell reports, 2022 - cell.com
Serine/arginine-rich splicing factor 3 (SRSF3) regulates mRNA alternative splicing of more
than 90% of protein-coding genes, providing an essential source for biological versatility …
than 90% of protein-coding genes, providing an essential source for biological versatility …
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells
Background Since FTO was recognized as the first m 6 A demethylase, the understanding of
its biological function has been widely expanded. However, the role of FTO in cervical …
its biological function has been widely expanded. However, the role of FTO in cervical …
Methyltransferase 3 mediated miRNA m6A methylation promotes stress granule formation in the early stage of acute ischemic stroke
W Si, Y Li, S Ye, Z Li, Y Liu, W Kuang… - Frontiers in molecular …, 2020 - frontiersin.org
The modification of methyltransferase-like (METTL) enzymes plays important roles in various
cellular responses by regulating microRNA expression. However, how m6A modification is …
cellular responses by regulating microRNA expression. However, how m6A modification is …
m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis
JJ He, Z Li, ZX Rong, J Gao, Y Mu, YD Guan… - Frontiers in …, 2020 - frontiersin.org
N6-methyladenosine (m6A) modification has been reported as a critical regulator of gene
transcript expression. Although m6A modification plays important roles in tumor …
transcript expression. Although m6A modification plays important roles in tumor …
Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …
structure is destroyed to the degree that bone becomes fragile and prone to fractures …
Deep6mAPred: A CNN and Bi-LSTM-based deep learning method for predicting DNA N6-methyladenosine sites across plant species
Abstract DNA N6-methyladenine (6mA) is a key DNA modification, which plays versatile
roles in the cellular processes, including regulation of gene expression, DNA repair, and …
roles in the cellular processes, including regulation of gene expression, DNA repair, and …
RNA N6-methyladenosine modification, spermatogenesis, and human male infertility
Z Cai, Y Niu, H Li - Molecular Human Reproduction, 2021 - academic.oup.com
Abstract RNA N6-methyladenosine (m6A) modification is one of the main forms of
posttranscriptional modification, and its dysregulation is involved in a series of pathological …
posttranscriptional modification, and its dysregulation is involved in a series of pathological …
CRISPR/Cas9-mediated LINC00511 knockout strategies, increased apoptosis of breast cancer cells via suppressing antiapoptotic genes
Background The growing detection of long noncoding RNAs (lncRNAs) required the
application of functional approaches in order to provide absolutely precise, conducive, and …
application of functional approaches in order to provide absolutely precise, conducive, and …