Anatomy of the antibody molecule - ScienceDirect Skip to main contentSkip to article Elsevier
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There are now several crystal structures of antibody Fab fragments complexed to their
protein antigens. These include Fab complexes with lysozyme, two Fab complexes with …

Forest fragmentation, the disruption in the continuity of forest habitat, is hypothesized to be a
major cause of population decline for some species of forest birds because fragmentation …

Shotgun scanning combinatorial mutagenesis was used to study the antigen-binding site of
Fab2C4, a humanized monoclonal antibody fragment that binds to the extracellular domain …

An altered antibody is produced by replacing the complementarity determining regions
(CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different …

We have used the polymerase chain reaction and VH family-based primers to clone and
sequence 74 human germline VH segments from a single individual and built a directory to …

During the past year, many new antibody structures have been determined, increasing our
understanding of these immunologically important molecules. Of special interest are new …

Publisher Summary This chapter describes the minimal antibody binding site through the
protein engineering of single-chain Fv analog and fusion proteins. In this approach, the …

We report the three-dimensional structures, at 1.8-A resolution, of the Fv fragment of the anti-
hen egg white lysozyme antibody D1. 3 in its free and antigen-bound forms. These …

Sequences of the third complementarity determining region of antibody heavy chains
(CDRH3s) are listed according to their length. Human sequences vary from 2 to 26 amino …