Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …

Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …

Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …

Background An unmet medical need exists for patients with metastatic renal cell carcinoma
who have progressed on VEGF-targeted and mTOR-inhibitor therapies. Fibroblast growth …

Simple Summary Deregulation of the FGF/FGFR axis is associated with many types of
cancer and contributes to the development of chemoresistance, limiting the effectiveness of …

During the past decade, incorporating anti-angiogenic agents into the therapeutic
management of a myriad of malignancies has in certain cases made a significant impact on …

Simple Summary Anti-angiogenic therapies targeting the vascular endothelial growth factor
(VEGF) signaling are established in the arsenal of cancer treatments. Despite the …

Tumor-associated macrophages (TAMs) derived from peripheral blood monocytes recruited
into the renal cell carcinoma (RCC) microenvironment. In response to inflammatory stimuli …

ABSTRACT Fibroblast Growth Factor (FGF) ligands and their receptors are crucial factors
driving chemoresistance in several malignancies, challenging the efficacy of currently …

Blood vessels nurture every part of the human body. Consequently, abnormalities in the
vasculature are closely associated with a variety of diseases, including cerebral stroke, heart …