Exosomes as mediators of intercellular crosstalk in metabolism
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
MicroRNA-21–dependent macrophage-to-fibroblast signaling determines the cardiac response to pressure overload
D Ramanujam, AP Schön, C Beck, P Vaccarello… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac macrophages (cMPs) are increasingly recognized as important
regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these …
regulators of myocardial homeostasis and disease, yet the role of noncoding RNA in these …
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila
L Worpenberg, C Paolantoni, S Longhi… - The EMBO …, 2021 - embopress.org
Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through
modulation of RNA metabolism. This modification is particularly enriched in the nervous …
modulation of RNA metabolism. This modification is particularly enriched in the nervous …
Screening of Drosophila microRNA-degradation sequences reveals Argonaute1 mRNA's role in regulating miR-999
MicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or
degradation. However, miRNA degradation can be triggered when extensively base-paired …
degradation. However, miRNA degradation can be triggered when extensively base-paired …
m6A RNA methylation regulates promoter-proximal pausing of RNA polymerase II
Summary RNA polymerase II (RNAP II) pausing is essential to precisely control gene
expression and is critical for development of metazoans. Here, we show that the m 6 A RNA …
expression and is critical for development of metazoans. Here, we show that the m 6 A RNA …
Genetics and epigenetics of bone remodeling and metabolic bone diseases
L Oton-Gonzalez, C Mazziotta, MR Iaquinta… - International Journal of …, 2022 - mdpi.com
Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation
Background Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to
associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated …
associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated …
What are the functional roles of Piwi proteins and piRNAs in insects?
Simple Summary Three small RNA pathways, representing miRNAs, siRNAs and piRNAs,
exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most …
exist in insects. Of the three pathways, piRNAs and Piwi proteins appear to have the most …
Epigenetic molecular mechanisms in insects
C Villagra, D Frías-Lasserre - Neotropical entomology, 2020 - Springer
Insects are the largest animal group on Earth both in biomass and diversity. Their
outstanding success has inspired genetics and developmental research, allowing the …
outstanding success has inspired genetics and developmental research, allowing the …