GATA transcription factor family members GATA1 and GATA2 play crucial roles in the
regulation of lineage-restricted genes during erythroid differentiation. GATA1 is …

Highlights•Endothelial cell-selective adhesion molecule (ESAM) marks hematopoietic stem
cells in humans as well as in mice.•ESAM enriches human hematopoietic stem cells in all …

Hematopoietic stem cells (HSCs) are defined by their capacity to self‐renew and to
differentiate into all blood cell lineages while retaining robust capacity to regenerate …

Human embryonic stem cell (hESC)-derived hematopoietic stem/progenitor cells hold
tremendous potential as alternative cell sources for the treatment of various hematological …

Induced pluripotent stem cells (iPSCs) can be generated from various types of cells with
transduction of defined transcription factors. In addition to regenerative medicine, iPSCs …

Blood agencies worldwide face the same recurring problem of enrolling healthy donors to
produce platelet concentrates (PC) to meet the fluctuating demand. Research in stem cell …

The recent advances in regenerative medicine, tissue engineering, and cellular therapies
combined with a better understanding of stem cell biology, have increased the demand for …

In deze masterproef wordt, aan de hand van een literatuurstudie, een overzicht aangeboden
van de uitdagingen en de vooruitgang die reeds geboekt werd bij de vorming van …

Aplastic anaemia (AA) is a disorder resulting in pancytopenia and hypocellular bone
marrow. Although the immunological nature of AA pathogenesis is widely accepted, there is …

Abstract Leukocyte Adhesion Defiency type III (LAD-III) is a rare congenital defect that affects
the normal adhesive function of phagocytic cells of the myeloid lineage. Bone marrow from a …