High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Abstract Background Polymorphonuclear neutrophils (PMNs) play an important role in
sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived …

Infection with SARS-CoV-2, the causative agent of the Coronavirus disease 2019 (COVID-
19) pandemic, causes respiratory problems and multifaceted organ dysfunction. A crucial …

Neutrophils are an absolutely essential part of the innate immune system, playing an
essential role in the control of infectious diseases but more recently are also being viewed …

The physiological and immune changes that occur during pregnancy are associated with
worsened disease outcomes during infection and sepsis. How these perturbations …

Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but
their contributions to rapid clinical deterioration and dysregulated inflammation have not …

Delayed wound healing causes problems for many patients both physically and
psychologically, contributing to pain, economic burden, loss of function, and even …

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Dietary phenolic acids alleviate intestinal inflammation through altering gut microbiota
composition and regulating macrophage activation. However, it is unclear how individual …