The mammalian START domain protein family in lipid transport in health and disease

BJ Clark - Journal of Endocrinology, 2012 - joe.bioscientifica.com
The gonadotropin FSH plays a key role in the control of Sertoli cell function. The FSH
molecular mechanism of action is best recognized for its stimulation of the adenylyl …

Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure

N Nagaya, K Kangawa - Regulatory peptides, 2003 - Elsevier
Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which
has been identified as an endogenous ligand for growth-hormone secretagogues receptor …

Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure

N Nagaya, J Moriya, Y Yasumura, M Uematsu, F Ono… - Circulation, 2004 - Am Heart Assoc
Background—Ghrelin is a novel growth hormone–releasing peptide that also induces
vasodilation, inhibits sympathetic nerve activity, and stimulates feeding through growth …

Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure

N Nagaya, M Uematsu, M Kojima, Y Ikeda… - Circulation, 2001 - Am Heart Assoc
Background—Ghrelin is a novel growth hormone (GH)–releasing peptide that may also
induce vasodilation and stimulate feeding through GH-independent mechanisms. We …

Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats

JY Min, Y Yang, KL Converso, L Liu… - Journal of Applied …, 2002 - journals.physiology.org
Massive loss of cardiac myocytes after myocardial infarction (MI) is a common cause of heart
failure. The present study was designed to investigate the improvement of cardiac function in …

Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy

KJ Osterziel, O Strohm, J Schuler, M Friedrich… - The Lancet, 1998 - thelancet.com
Background Some studies have suggested that treatment with recombinant human growth
hormone (rhGH) increases left-ventricular mass and improves haemodynamic and …

Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x

DJ Ing, J Zang, VJ Dzau, KA Webster… - Circulation …, 1999 - Am Heart Assoc
Cytokine-induced NO production depresses myocardial contractility and has been shown to
be cytotoxic to cardiac myocytes. However, the mechanisms of cytokine-induced cardiac …

Neutralization of interleukin-1β in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling

MW Hwang, A Matsumori, Y Furukawa, K Ono… - Journal of the American …, 2001 - jacc.org
OBJECTIVES We sought to examine the role of the pro-inflammatory cytokine, interleukin-1-
beta (IL-1β), in the process of left ventricular (LV) remodeling in the early phase after …

Insulin-like Growth Factor-1 but Not Growth Hormone Augments Mammalian Myocardial Contractility by Sensitizing the Myofilament to Ca2+ Through a Wortmannin …

A Cittadini, Y Ishiguro, H Strömer, M Spindler… - Circulation …, 1998 - Am Heart Assoc
A growing body of evidence has been accumulated recently suggesting that growth
hormone (GH) and insulin-like growth factor-1 (IGF-1) affect cardiac function, but their …

Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction

RM Kanashiro-Takeuchi, K Tziomalos… - Proceedings of the …, 2010 - National Acad Sciences
Whether the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis exerts
cardioprotective effects remains controversial; and the underlying mechanism (s) for such …