Evidence demonstrates that chronic caffeine exposure, primarily through consumption of
coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies …

Alcoholism is a serious public health concern that is characterized by the development of
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial
hemiplegic migraine type 2: FHM 2) is caused by loss‐of‐function mutations in α2 Na+, K+ …

The development of new treatments for substance use disorders requires identification of
targetable molecular mechanisms. Pathology in glutamatergic neurotransmission system in …

Alteration of glutamatergic-neurotransmission is a hallmark of alcohol dependence. We
have previously reported that chronic ethanol-drinking downregulated glutamate transporter …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

Clinical and preclinical research have identified sex differences in substance use and
addiction-related behaviors. Historically, substance use disorders are more prevalent in men …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the
initiation and development of alcohol and drug dependence. Alcohol consumption induced …

Dysregulation of glutamate homeostasis is a well-established core feature of
neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate …