Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Inorganic and bioinorganic solvent exchange mechanisms

L Helm, AE Merbach - Chemical reviews, 2005 - ACS Publications
The simplest reaction on a metal ion in aqueous or nonaqueous solution is the exchange of
a solvent molecule between the first and second coordination shells (eq 1). This reaction is …

Magnetic resonance imaging contrast agents: overview and perspectives

GP Yan, L Robinson, P Hogg - Radiography, 2007 - Elsevier
Magnetic resonance imaging (MRI) is a non-invasive clinical imaging modality, which has
become widely used in the diagnosis and/or staging of human diseases around the world …

Small molecular gadolinium (III) complexes as MRI contrast agents for diagnostic imaging

KWY Chan, WT Wong - Coordination Chemistry Reviews, 2007 - Elsevier
Magnetic resonance imaging (MRI) contrast agents that contain the gadolinium ion are
widely used in biomedical research and diagnosis. The relaxation mechanism of these T1 …

Dendrimers based cancer nanotheranostics: An overview

V Saluja, Y Mishra, V Mishra, N Giri, P Nayak - International Journal of …, 2021 - Elsevier
Cancer is a known deadliest disease that requires a judicious diagnostic, targeting, and
treatment strategy for an early prognosis and selective therapy. The major pitfalls of the …

Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration

E Boros, CL Ferreira, JF Cawthray… - Journal of the …, 2010 - ACS Publications
We have investigated novel bifunctional chelate alternatives to the aminocarboxylate
macrocycles NOTA (N3O3) or DOTA (N4O4) for application of radioisotopes of Ga to …

Modern developments in bifunctional chelator design for gallium radiopharmaceuticals

PRWJ Davey, BM Paterson - Molecules, 2022 - mdpi.com
The positron-emitting radionuclide gallium-68 has become increasingly utilised in both
preclinical and clinical settings with positron emission tomography (PET). The synthesis of …

Macrocyclic receptor exhibiting unprecedented selectivity for light lanthanides

A Roca-Sabio, M Mato-Iglesias… - Journal of the …, 2009 - ACS Publications
We report a new macrocyclic ligand, N, N′-bis [(6-carboxy-2-pyridil) methyl]-4, 13-diaza-18-
crown-6 (H2bp18c6), designed for complexation of lanthanide ions in aqueous solution …

H4octapa: An Acyclic Chelator for 111In Radiopharmaceuticals

EW Price, JF Cawthray, GA Bailey… - Journal of the …, 2012 - ACS Publications
This preliminary investigation of the octadentate acyclic chelator H4octapa (N4O4) with
111In/115In3+ has demonstrated it to be an improvement on the shortcomings of the current …

Monopicolinate cyclen and cyclam derivatives for stable copper (II) complexation

LMP Lima, D Esteban-Gómez, R Delgado… - Inorganic …, 2012 - ACS Publications
The syntheses of a new 1, 4, 7, 10-tetraazacyclododecane (cyclen) derivative bearing a
picolinate pendant arm (H L1), and its 1, 4, 8, 11-tetraazacyclotetradecane (cyclam) …