Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) and tau deposition in brain. It
has emerged that Aβ toxicity is tau dependent, although mechanistically this link remains …

The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form
new memories. For many years, this dementia was attributed to nerve-cell death induced by …

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

Thrombo-occlusive cerebrovascular disease resulting in stroke and permanent neuronal
loss is an important cause of morbidity and mortality. Because of the unique properties of …

While prevailing evidence supports that the amyloid cascade hypothesis is a key component
of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …

The tumor necrosis factor type 1 death receptor (TNFR1) contributes to apoptosis. TNFR1, a
subgroup of the TNFR superfamily, contains a cytoplasmic death domain. We recently …