Switches between different behavioral states of the animal are associated with prominent
changes in global brain activity, between sleep and wakefulness or from inattentive to …

Traditional descriptions of the cortical cholinergic input system focused on the diffuse
organization of cholinergic projections and the hypothesis that slowly changing levels of …

Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and
attention. They collectively innervate the entire cerebral cortex, differentially controlling …

The basal forebrain contains several interdigitating anatomical structures, including the
diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also cell …

Cholinergic projections to the cortex and hippocampus mediate fundamental cognitive
processes. The capacity of the high-affinity choline uptake transporter (CHT) to import …

Importance The extent of dorsolateral prefrontal cortex (DLPFC) plasticity in Alzheimer
disease (AD) and its association with working memory are not known. Objectives To …

Cortical neurons process information on a background of spontaneous, ongoing activity with
distinct spatiotemporal profiles defining different cortical states. During wakefulness, cortical …

Top-down signals from frontal cortex are thought to be important in cognitive control of
sensory processing. To explore this interaction, we compared activity in ferret frontal cortex …

The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a
conglomerate of highly specialized brain areas and has been implicated to have a role in …

Evidence from lesion and cortical-slice studies implicate the neocortical cholinergic system
in the modulation of sensory, attentional and memory processing. In this review we consider …