The incidence of diabetes mellitus (DM) continues to rise and has quickly become one of the
most prevalent and costly chronic diseases worldwide. A close link exists between DM and …

Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

Eighty percent of patients with diabetes mellitus die a thrombotic death. Seventy-five percent
of these deaths is due to cardiovascular complications, and the remainder is due to …

Introduction: The close relationship existing between aging and thrombosis has growingly
been studied in this last decade. The age‐related development of a prothrombotic …

Plasminogen activator inhibitor 1 (PAI-1) is a member of the serine protease inhibitor
(serpin) superfamily. PAI-1 is the principal inhibitor of the plasminogen activators, tissue …

The development of coronary artery disease, and specifically myocardial infarction, involves
hyperplasia of arterial smooth muscle, the development of fatty streaks, atheroma formation …

Summary Plasminogen activator inhibitor‐1 (PAI‐1) is the major physiologic inhibitor of
tissue‐type plasminogen activator in plasma, and is elevated in a variety of clinical situations …

The link between plasminogen activator inhibitor (PAI)-1 and the metabolic syndrome with
obesity was established many years ago. Increased PAI-1 level can be now considered a …

Insulin resistance is defined as a clinical state in which a normal or elevated insulin level
produces an attenuated biologic response. Specifically, the biologic response most studied …

The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …