Our daily rhythmicity is controlled by a circadian clock with a specific set of genes located in
the suprachiasmatic nucleus in the hypothalamus. Mast cells (MCs) are major effector cells …

Highlights•Sleep disturbances are observed at high rates within trauma-exposed groups
and contribute to the development and maintenance of PTSD.•Cognitive-behavioral therapy …

Objective To evaluate the dose–response relationship of daridorexant, a new dual orexin
receptor antagonist, on sleep variables in subjects with insomnia disorder. Methods Adults …

Abstract Background and Objective Daridorexant is a dual orexin receptor antagonist for the
treatment of insomnia. In two phase III, 12-week studies in patients with insomnia disorder …

Background This study focuses on seven commonly used hypnotics to comprehensively
analyze the effects of long-and short-term use on sleep outcomes among adults and older …

The bidirectional communication between the gastrointestinal tract and the central nervous
system appears to be functionally linked to the intestinal microbiome, namely the …

Introduction Insomnia and vasomotor symptoms are frequently experienced during the
menopausal transition and in postmenopause, worsening sleep maintenance and quality of …

Abstract Background and Objective The dual orexin receptor antagonist daridorexant,
studied in two phase III trials, dose-dependently improved objective and subjective sleep …

Study objectives Although insomnia is common among cancer patients, its prevalence
remains variable, and its risk factors and correlation with other cancer-related symptoms are …

Insomnia is very prevalent in psychiatry and is considered a transdiagnostic symptom of
mental disorders. Yet, it is not only a consequence of a mental condition but may also exert …