Borrowing using historical-bias power prior with empirical Bayes
HY Lin, E Slate - Journal of Biopharmaceutical Statistics, 2024 - Taylor & Francis
Adaptively incorporating historical information into analyses of current data can improve the
precision of inference without requiring additional new observation. Unfortunately, not all …
precision of inference without requiring additional new observation. Unfortunately, not all …
Utilization of treatment effect on a surrogate endpoint for planning a study to evaluate treatment effect on a final endpoint
To design a phase III study with a final endpoint and calculate the required sample size for
the desired probability of success, we need a good estimate of the treatment effect on the …
the desired probability of success, we need a good estimate of the treatment effect on the …
Integration of Efficacy Biomarkers Together with Toxicity Endpoints in Immune-Oncology Dose Finding Studies
The primary objective of phase I oncology studies is to establish the safety profile of a new
treatment and determine the maximum tolerated dose (MTD). This is motivated by the …
treatment and determine the maximum tolerated dose (MTD). This is motivated by the …