Bladder cancer is the tenth most common cancer type worldwide. Urothelial carcinoma is the
most common type of bladder cancer and accounts for 90% of bladder cancer cases in the …

Enfortumab vedotin is a first-in-class Nectin-4-directed antibody-drug conjugate approved by
the US Food and Drug Administration for the treatment of patients with locally advanced or …

PURPOSE Locally advanced or metastatic urothelial carcinoma is an incurable disease with
limited treatment options, especially for patients who were previously treated with platinum …

The identification of optimal target antigens on tumor cells is central to the advancement of
new antibody-based cancer therapies. We performed suppression subtractive hybridization …

Aneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no
general theory to explain the recurring patterns of aneuploidy in cancer has emerged. Here …

Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence
supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells …

Increases in lipid peroxidation can cause ferroptosis, a form of cell death triggered by
inhibition of glutathione peroxidase 4 (GPX4), which catalyzes the reduction of lipid …

Cell–cell adhesive processes are central to the physiology of multicellular organisms. A
number of cell surface molecules contribute to cell–cell adhesion, and the dysfunction of …

The Nectin cell adhesion molecule (Nectin) family members are Ca 2+‑independent
immunoglobulin‑like cellular adhesion molecules (including Nectins 1‑4), involved in cell …

Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The
management of metastasis has evolved by focusing on controlling the growth of the disease …