[HTML][HTML] The skin barrier: an extraordinary interface with an exceptional lipid organization
The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …
Ceramide: a simple sphingolipid with unique biophysical properties
BM Castro, M Prieto, LC Silva - Progress in lipid research, 2014 - Elsevier
Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …
functions are thought to depend on ceramides' unique biophysical properties, which …
Using molecular simulation to understand the skin barrier
Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …
[HTML][HTML] Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids
Some of the simplest sphingolipids, namely sphingosine, ceramide, some closely related
molecules (eicosasphingosine, phytosphingosine), and their phosphorylated compounds …
molecules (eicosasphingosine, phytosphingosine), and their phosphorylated compounds …
[HTML][HTML] The importance of hydrogen bonding in sphingomyelin's membrane interactions with co-lipids
JP Slotte - Biochimica Et Biophysica Acta (BBA)-Biomembranes, 2016 - Elsevier
Sphingomyelin is an important constituent of mammalian cell membranes. Its molecular
structure is N-acyl-d-erythro-sphingosylphosphorylcholine. The N-acyls in sphingomyelin …
structure is N-acyl-d-erythro-sphingosylphosphorylcholine. The N-acyls in sphingomyelin …
Vectorial budding of vesicles by asymmetrical enzymatic formation of ceramide in giant liposomes
JM Holopainen, MI Angelova, PKJ Kinnunen - Biophysical journal, 2000 - cell.com
Sphingomyelin is an abundant component of eukaryotic membranes. A specific enzyme,
sphingomyelinase can convert this lipid to ceramide, a central second messenger in cellular …
sphingomyelinase can convert this lipid to ceramide, a central second messenger in cellular …
[HTML][HTML] Effects of ceramide and other simple sphingolipids on membrane lateral structure
The available data concerning the ability of ceramide and other simple sphingolipids to
segregate laterally into rigid, gel-like domains in a fluid bilayer has been reviewed …
segregate laterally into rigid, gel-like domains in a fluid bilayer has been reviewed …
Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane
JM Holopainen, M Subramanian, PKJ Kinnunen - Biochemistry, 1998 - ACS Publications
The behaviors of two chemically well-defined sphingolipids, N-palmitoyl-sphingomyelin
(C16: 0-SM) and the corresponding ceramide (C16: 0-Cer), in a 1-palmitoyl-2-oleoyl-sn …
(C16: 0-SM) and the corresponding ceramide (C16: 0-Cer), in a 1-palmitoyl-2-oleoyl-sn …
[HTML][HTML] The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics
The lipids of the topmost layer of the skin, the stratum corneum, represent the primary barrier
to molecules penetrating the skin. One approach to overcoming this barrier for the purpose …
to molecules penetrating the skin. One approach to overcoming this barrier for the purpose …
Ceramides in phospholipid membranes: effects on bilayer stability and transition to nonlamellar phases
The effects of ceramides of natural origin on the gel-fluid and lamellar-inverted hexagonal
phase transitions of phospholipids (mainly dielaidoylphosphatidylethanolamine) have been …
phase transitions of phospholipids (mainly dielaidoylphosphatidylethanolamine) have been …