Application of Caenorhabditis elegans in Lipid Metabolism Research

L An, X Fu, J Chen, J Ma - International journal of molecular sciences, 2023 - mdpi.com
Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

The role of lipids in aging-related metabolic changes

I de Diego, S Peleg, B Fuchs - Chemistry and physics of lipids, 2019 - Elsevier
Fat is historically associated with poor health and obesity. However, the continuous use of
lipidomics and genetic studies in model organisms revealed that specific lipid profiles and …

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

A Annibal, RG Tharyan, MF Schonewolff, H Tam… - Nature …, 2021 - nature.com
The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …

NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin

RG Tharyan, A Annibal, I Schiffer, R Laboy… - Nature …, 2020 - nature.com
Mitochondria are multidimensional organelles whose activities are essential to cellular
vitality and organismal longevity, yet underlying regulatory mechanisms spanning these …

Practical benzylation of N,N‐substituted ethanolamines related to chemical warfare agents for analysis and detection by electron ionization gas chromatography …

CA Valdez, AK Vu, S Hok… - Journal of Forensic …, 2023 - Wiley Online Library
The benzylation of three low molecular weight N, N‐disubstituted ethanolamines related to
chemical warfare agents (CWAs) to furnish derivatives with improved gas chromatography …

Determination of N,N-Dialkylethanolamines Related to Chemical Warfare Agents as Benzylated Species in an OPCW Proficiency Test Soil Sample by Electron …

CA Valdez, S Hok, DS Cho, AK Vu - Analytical Letters, 2024 - Taylor & Francis
In the field of chemical warfare agents (CWAs), ethanolamines are important building blocks
for the preparation of nerve agents belonging to the V-series such as VX and VR as well as …

Optimization of mass spectrometry settings for steroidomic analysis in young and old killifish

R Dabrowski, R Ripa, C Latza, A Annibal… - Analytical and …, 2020 - Springer
Steroids are essential structural components of cell membranes that organize lipid rafts and
modulate membrane fluidity. They can also act as signalling molecules that work through …

Comparison of ESI‐MS/MS and APCI‐MS methods for the quantification of folic acid analogs in C. elegans

A Annibal, H Tam, C Latza… - Journal of Mass …, 2019 - Wiley Online Library
Folic acid (FA) plays a vital role in central metabolism, including the one carbon cycle,
nucleotide, and amino acid biosynthesis. The development of sensitive, accurate analytical …

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans

JF de Luco, G Prez, BH Cravero, D De Mendoza… - JoVE (Journal of …, 2019 - jove.com
This work presents a method to prepare an analytical standard to analyze 2-arachidonoyl
glycerol (2-AG) qualitatively and quantitatively by liquid chromatography-electrospray …