Forced degradation and impurity profiling: recent trends in analytical perspectives

D Jain, PK Basniwal - Journal of pharmaceutical and biomedical analysis, 2013 - Elsevier
This review describes an epigrammatic impression of the recent trends in analytical
perspectives of degradation and impurities profiling of pharmaceuticals including active …

Related impurities in peptide medicines

M D'Hondt, N Bracke, L Taevernier, B Gevaert… - … of pharmaceutical and …, 2014 - Elsevier
Peptides are an increasingly important group of pharmaceuticals, positioned between
classic small organic molecules and larger bio-molecules such as proteins. Currently, the …

Pharmaceutical impurities and degradation products: Uses and applications of NMR techniques

RM Maggio, NL Calvo, SE Vignaduzzo… - … of pharmaceutical and …, 2014 - Elsevier
Current standards and regulations demand the pharmaceutical industry not only to produce
highly pure drug substances, but to achieve a thorough understanding of the impurities …

Establishment of measurement traceability for peptide and protein quantification through rigorous purity assessment—a review

RD Josephs, G Martos, M Li, L Wu, JE Melanson… - Metrologia, 2019 - iopscience.iop.org
The health of their populations and efficient health care systems are of critical importance to
the economic and social well-being of nations. Accurate and comparable peptide/protein …

Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas

EM Egido, R Hernández, J Marco, RA Silvestre - Regulatory peptides, 2009 - Elsevier
Obestatin is a 23-amino acid peptide derived from preproghrelin, purified from stomach
extracts and detected in peripheral plasma. In contrast to ghrelin, obestatin has been …

Quality specifications for peptide drugs: a regulatory‐pharmaceutical approach

V Vergote, C Burvenich, C Van de Wiele… - Journal of peptide …, 2009 - Wiley Online Library
Peptide drugs, as all types of pharmaceuticals, require adequate specifications (ie quality
attributes, procedures and acceptance criteria) as part of their quality assurance to ensure …

Falsification of biotechnology drugs: current dangers and/or future disasters?

S Janvier, B De Spiegeleer, C Vanhee… - … of pharmaceutical and …, 2018 - Elsevier
Falsified medical products have become a global threat since they were first mentioned to
the general public at the conference of experts on the rational use of drugs organized by the …

Role of GPR39 in neurovascular homeostasis and disease

Y Xu, AP Barnes, NJ Alkayed - International journal of molecular sciences, 2021 - mdpi.com
GPR39, a member of the ghrelin family of G protein-coupled receptors, is zinc-responsive
and contributes to the regulation of diverse neurovascular and neurologic functions …

Building parity between brand and generic peptide products: Regulatory and scientific considerations for quality of synthetic peptides

LC Wu, F Chen, SL Lee, A Raw… - International Journal of …, 2017 - Elsevier
Peptides are a fast growing segment in the pharmaceutical industry. Consequently, the
industry and regulatory agencies are increasing their focus on the regulatory path and …

Obestatin, obesity and diabetes

AJ Ren, ZF Guo, YK Wang, L Lin, X Zheng, WJ Yuan - Peptides, 2009 - Elsevier
The high prevalence of obesity and diabetes will lead to higher rates of morbidity and
mortality. It is well known that ghrelin plays a potential role in obesity and diabetes …