Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …

Prime editing systems have enabled the incorporation of precise edits within a genome
without introducing double strand breaks. Previous studies defined an optimal primer …

p300 and CREB-binding protein (CBP) are ubiquitously expressed pleiotropic lysine
acetyltransferases and play a key role as transcriptional co-activators that are essential for a …

MYC is one of the most important oncogenes in cancer. Indeed, MYC is upregulated in 50–
60% of all tumors. MYC overexpression can be achieved through a variety of mechanisms …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

Acute myeloid leukemia (AML) harboring inv (16)(p13q22) expresses high levels of miR-
126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 …

Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-
restricted epigenetic and transcriptional regulatory networks. Here, by integrating super …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …

Evasion from drug-induced apoptosis is a crucial mechanism of cancer treatment resistance.
The proapoptotic protein NOXA marks an aggressive pancreatic ductal adenocarcinoma …