Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Density functional theory, molecular docking, In vitro and In vivo anti-inflammatory investigation of lapachol isolated from Fernandoa adenophylla
Medicinal plants are the main source of active chemical constituents responsible for curing
or mitigating various ailments. To discover new, safe, and effective drug candidates the …
or mitigating various ailments. To discover new, safe, and effective drug candidates the …
Virtual screening of citrus flavonoid tangeretin: A promising pharmacological tool for the treatment and prevention of Zika fever and COVID-19
It is of great importance for the pharmaceutical industry to find therapeutic substances
extracted from natural sources, which are abundant, obtained with low costs and presenting …
extracted from natural sources, which are abundant, obtained with low costs and presenting …
Synthesis, single crystal X-ray, DFT, spectroscopic, molecular docking studies and in vitro biological evaluation of compound N-benzyl-4-(4-chlorophenyl)-2 …
Several α-ketoamides from natural as well as synthetic sources have been shown to
possess multitude of biological activities due to their versatile nature and presence of …
possess multitude of biological activities due to their versatile nature and presence of …
[PDF][PDF] Methylcytisine alcaloid potentially active against dengue virus: a molecular docking study and electronic structural characterization
Dengue fever is a serious disease acquired from the Aedes aegypti mosquito present in
tropical and subtropical regions, deeply impacting the population's quality of life. Its control …
tropical and subtropical regions, deeply impacting the population's quality of life. Its control …
Fluorine derivatives of piceatannol for photobiological and photophysical applications by DFT approach
In the present work, we have calculated the electrical and optical properties of pure
piceatannol (PI) and its six fluorinated derivatives (F1-F6). The first-principles calculations …
piceatannol (PI) and its six fluorinated derivatives (F1-F6). The first-principles calculations …
Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives
In the current era, a potent drug is still needed on the market for the treatment of various
diseases worldwide. Researchers mainly focus on those enzymes that cause these …
diseases worldwide. Researchers mainly focus on those enzymes that cause these …
Discovery of new molecular hybrid derivatives with coumarin scaffold bearing pyrazole/oxadiazole moieties: Molecular docking, POM analyses, in silico …
G Tataringa, C Tuchilus, M Ahmed, S Ahmed… - Bioorganic …, 2024 - Elsevier
This synthetic organic methodology involves the creation of novel coumarin-based hybrids
of series (1–4) with pyrazole ring and (5–8) with oxadiazole moiety. The targeted …
of series (1–4) with pyrazole ring and (5–8) with oxadiazole moiety. The targeted …
Unraveling the inhibitory potential of fatty acids from Cola lepidota seed against monoclonal antibody Fab fragment (9F8) (3VG0) leptin antagonism and restoration of …
Obesity represents a significant global health issue that continues to escalate in prevalence.
Interestingly, there is a less explored connection between obesity and compromised leptin …
Interestingly, there is a less explored connection between obesity and compromised leptin …
Pyrazole-Thiazole Hybrids: Synthesis, Computational Studies and Impact on Digestive Enzymes
In this study, the syntheses of some pyrazole-thiazole hybrids and their cyanoacrylate
derivatives have been reported. 1 H NMR, 13 C NMR, LC-MS, and IR spectroscopy were …
derivatives have been reported. 1 H NMR, 13 C NMR, LC-MS, and IR spectroscopy were …