The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the
least studied structures of the central nervous system (CNS) despite its clinical importance …

The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

The choroid plexus is situated at an anatomically and functionally important interface within
the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the …

Iron (Fe) and copper (Cu) are essential to neuronal function; excess or deficiency of either is
known to underlie the pathoetiology of several commonly known neurodegenerative …

Abstract Lipocalin-2 (LCN2) is an acute-phase protein that, by binding to iron-loaded
siderophores, acts as a potent bacteriostatic agent in the iron-depletion strategy of the …

Adaptive immunity was repeatedly shown to play a role in maintaining lifelong brain
function. Under physiological conditions, this activity was associated with CD4+ T cells …

Theories for restless legs syndrome (RLS) pathogenesis include iron deficiency, dopamine
dysregulation and peripheral neuropathy. Increased prevalence of small intestinal bacterial …

Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest
that there are two sources of hepcidin in the brain; one is local and the other comes from the …