The mechanisms of silkworm resistance to the baculovirus and antiviral breeding

Z Hu, F Zhu, K Chen - Annual Review of Entomology, 2023 - annualreviews.org
Silkworm (Bombyx mori) is not only an economic insect but also a model organism for life
science research. Bombyx mori nucleopolyhedrovirus (BmNPV) disease is a major …

CRISPR/Cas9 in lepidopteran insects: Progress, application and prospects

JJ Li, Y Shi, JN Wu, H Li, G Smagghe, TX Liu - Journal of insect physiology, 2021 - Elsevier
Clustered regularly spaced short palindrome repeats (CRISPR) structure family forms the
acquired immune system in bacteria and archaea. Recent advances in CRISPR/Cas …

Efficient inhibition of African swine fever virus replication by CRISPR/Cas9 targeting of the viral p30 gene (CP204L)

A Hübner, B Petersen, GM Keil, H Niemann… - Scientific reports, 2018 - nature.com
African swine fever is a devastating viral disease of domestic and wild pigs against which no
vaccine or therapy is available. Therefore, we applied the CRISPR (clustered regularly …

Insights Into the Antiviral Pathways of the Silkworm Bombyx mori

L Jiang - Frontiers in immunology, 2021 - frontiersin.org
The lepidopteran model silkworm, Bombyx mori, is an important economic insect. Viruses
cause serious economic losses in sericulture; thus, the economic importance of these …

Transgenic expression of antimicrobial peptides from black soldier fly enhance resistance against entomopathogenic bacteria in the silkworm, Bombyx mori

J Xu, X Luo, G Fang, S Zhan, J Wu, D Wang… - Insect Biochemistry and …, 2020 - Elsevier
Antimicrobial peptides (AMPs) are effective molecules produced by the innate immune
system of most organisms to fend off invading microbes and regarded as promising …

Advances in the arms race between silkworm and baculovirus

L Jiang, MR Goldsmith, Q Xia - Frontiers in Immunology, 2021 - frontiersin.org
Insects are the largest group of animals. Nearly all organisms, including insects, have viral
pathogens. An important domesticated economic insect is the silkworm moth Bombyx mori …

CRISPR/Cas9-mediated Serine protease 2 disruption induces male sterility in Spodoptera litura

H Bi, X Xu, X Li, Y Wang, S Zhou, Y Huang - Frontiers in physiology, 2022 - frontiersin.org
Male fertility is essential for reproduction and population growth in animals. Many factors
affect male fertility, such as courtship behavior, sperm quantity, and sperm motility, among …

The application of CRISPR/Cas systems for antiviral therapy

HJE Baddeley, M Isalan - Frontiers in Genome Editing, 2021 - frontiersin.org
As CRISPR/Cas systems have been refined over time, there has been an effort to apply
them to real world problems, such as developing sequence-targeted antiviral therapies …

CRISPR/Cas12a Mediated Genome Editing Enhances Bombyx mori Resistance to BmNPV

Z Dong, Q Qin, Z Hu, X Zhang, J Miao… - … in Bioengineering and …, 2020 - frontiersin.org
CRISPR/Cas12a (Cpf1) is a single RNA-guided endonuclease that provides new
opportunities for targeted genome engineering through the CRISPR/Cas9 system. Only …

Advances in Editing Silkworms (Bombyx mori) Genome by Using the CRISPR-Cas System

GM Baci, AA Cucu, AI Giurgiu, AS Muscă, L Bagameri… - Insects, 2021 - mdpi.com
Simple Summary One of the most powerful gene editing approaches is the CRISPR
(clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) tool …