Background Dementia is a progressive global cognitive impairment syndrome. In 2010,
more than 35 million people worldwide were estimated to be living with dementia. Some …

Background Dementia is a progressive global cognitive impairment syndrome. In 2010,
more than 35 million people worldwide were estimated to be living with dementia. Some …

The amyloid cascade hypothesis is widely accepted as the centerpiece of Alzheimer
disease (AD) pathogenesis. It proposes that abnormal production of beta amyloid protein …

Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests
clinically as an isolated amnestic deficit that progresses to a characteristic dementia …

Background Mild cognitive impairment (MCI) due to Alzheimer's disease is the symptomatic
predementia phase of Alzheimer's disease dementia, characterised by cognitive and …

Two basic discoveries spurred research into inflammation as a driving force in the
pathogenesis of Alzheimer's disease (AD). The first was the identification of activated …

Background Cerebrospinal fluid (CSF) biomarkers β-amyloid 1-42 (Aβ 1-42), also expressed
as Aβ 1-42: Aβ 1-40 ratio, T-tau, and P-tau 181P, have proven diagnostic accuracy for mild …

Background ¹⁸F‐FDFG uptake by brain tissue as measured by positron emission
tomography (PET) is a well‐established method for assessment of brain function in people …

Identifying individuals destined to develop Alzheimer's dementia within time frames
acceptable for clinical trials constitutes an important challenge to design studies to test …