Accurate chromosome segregation is vital for cell and organismal viability. The mitotic
spindle, a bipolar macromolecular machine composed largely of dynamic microtubules, is …

Accurate chromosome segregation in mitosis relies on sister kinetochores forming stable
attachments to microtubules (MTs) extending from opposite spindle poles and establishing …

Accurate chromosome segregation relies on kinetochores carrying out multiple functions,
including establishing and maintaining microtubule attachments, forming precise bi-oriented …

Objectives The promoting roles of cyclin dependent kinase 1 (CDK1) have been revealed in
various tumors, however, its effects in the progression of cancer stem cells are still …

Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …

Dividing cells detect and correct erroneous kinetochore–microtubule attachments during
mitosis, thereby avoiding chromosome missegregation. The Aurora B kinase phosphorylates …

The conserved Ndc80 kinetochore complex, Ndc80c, is the principal link between mitotic
spindle microtubules and centromere-associated proteins. We used AlphaFold 2 (AF2) to …

Chromosome segregation requires sister kinetochores to attach microtubules emanating
from opposite spindle poles. Proper attachments come under tension and are stabilized, but …

Accurate chromosome segregation relies on kinetochores carrying out multiple functions,
including establishing and maintaining microtubule attachments, forming precise bioriented …

The kinetochore is a mega-dalton protein assembly that forms within centromeric regions of
chromosomes and directs their segregation during cell division. Here we review cell cycle …