Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Neurodegenerative diseases share the fact that they derive from altered proteins that
undergo an unfolding process followed by formation of β-structures and a pathological …

First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously
expressed throughout mammalian cells. It regulates both transcriptional activation and …

Background. Parkinson's disease (PD) is a common neurodegenerative disease associated
with accumulation of misfolding proteins and increased neuroinflammation, which may …

Abstract Background Neurodegenerative diseases (NDDs) are characterized by progressive
neuronal dysfunctionality which results in disability and human life-threatening events. In …

Oxidative stress reflects an imbalance between the production of reactive oxygen species
(ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and …

Parkinson's disease (PD) is defined as a chronic neurodegenerative disorder which is
diagnosed mostly by its clinical manifestations. Reactive oxygen species (ROS) are …

The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2
(Nrf2) pathway serves as a crucial regulator against oxidative stress (OS) damage in various …

Parkinson's disease (PD) is a prevalent neurodegenerative aging disorder that manifests as
motor and non-motor symptoms, and its etiopathogenesis is influenced by non-coding RNAs …

Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and
oxidative stress play key etiopathological role. The pathology of PD brain is characterized by …