Neurodegenerative diseases resulting from the progressive loss of structure and/or function
of neurons contribute to different paralysis degrees and loss of cognition and sensation. The …

The lack of curative therapies for neurodegenerative diseases has high economic impact
and places huge burden on the society. The contribution of stem cells to cure …

Mechanisms for breast cancer metastasis remain unclear. Whether truncated glioma-
associated oncogene homolog 1 (TGLI1), a transcription factor known to promote …

Despite the therapeutic promise of direct reprogramming, basic principles concerning fate
erasure and the mechanisms to resolve cell identity conflicts remain unclear. To tackle these …

Parkinson's disease (PD) is a neurodegenerative disease attributed to the loss of midbrain
dopaminergic (DA) neurons. The current lack of predictive models for this disease has been …

Encouraging recent data on the molecular pathways underlying aging have identified
variants and expansions of genes associated with DNA replication and repair, telomere and …

Mesodiencephalic dopaminergic (mdDA) neurons are located in the ventral
mesodiencephalon and are involved in psychiatric disorders and severely affected in …

Stem cell transplantation is one of the most promising yet enigmatic treatments for spinal
cord injury (SCI), a common problem in dogs. As pre-differentiated mesenchymal stem cells …

Clinical trials engrafting human fetal ventral mesencephalic tissue have demonstrated, in
principle, that cell replacement therapy provides substantial long-lasting improvement of …

DNA methylation is an important epigenetic modification involved in many biological
processes and diseases. Many studies have mapped DNA methylation changes associated …