Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Currently, cancer is still a leading cause of human death globally. Tumor deterioration
comprises multiple events including metastasis, therapeutic resistance and immune …

Immune evasion and metabolic reprogramming are hallmarks of cancer progression often
associated with a poor prognosis and frequently present significant challenges for cancer …

From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently
have described toxins that inhibited platelet aggregation and cancer cell migration. In this …

The high incidence of epithelial malignancies in HIV-1 infected individuals is associated with
co-infection with oncogenic viruses, such as high-risk human papillomaviruses (HR HPVs) …

Background: Breast cancers are heterogeneous and are classified according to the
expression of ER, PR and HER2 receptors to distinct groups with prognostic and therapeutic …

Single cancer cells within a tumor exhibit variable levels of resistance to drugs, ultimately
leading to treatment failures. While tumor heterogeneity is recognized as a major obstacle to …

Heterogeneities among tumor cells significantly contribute towards cancer progression and
therapeutic inefficiency. Hence, understanding the nature of cancer through liquid biopsies …

Abstract The PI3K, AKT, and mTOR (PAM) pathway is frequently dysregulated in breast
cancer (BC) to accommodate high catabolic and anabolic activities driving tumor growth …

The extracellular matrix (ECM) is a dynamic and complex microenvironment that modulates
cell behavior and cell fate. Changes in ECM composition and architecture have been …