According to present concepts, innate immunity is regulated by receptors that determine
danger levels by responding to molecules that are associated with infection or cellular …

Natural killer (NK) cells are lymphocytes of the innate immune system that monitor cell
surfaces of autologous cells for an aberrant expression of MHC class I molecules and cell …

Exosomes are nanovesicles released by normal and tumor cells, which are detectable in
cell culture supernatant and human biological fluids, such as plasma. Functions of …

Freshly isolated, resting natural killer (NK) cells are generally less lytic against target cells
than in vitro interleukin 2 (IL-2)-activated NK cells. To investigate the basis for this difference …

Ligands for the NKG2D stimulatory receptor are frequently upregulated on tumor lines,
rendering them sensitive to natural killer (NK) cells, but the role of NKG2D in tumor …

Natural-killer (NK) cells form a first line of defence against pathogens or host cells that are
stressed and/or cancerous. NK cells express surface receptors that receive signals from the …

The surface density of the triggering receptors responsible for the natural killer (NK)-
mediated cytotoxicity is crucial for the ability of NK cells to kill susceptible target cells. In this …

Natural killer cells are innate immune cells that control certain microbial infections and
tumours. The function of natural killer cells is regulated by a balance between signals …

Despite advances in the diagnostic and therapeutic modalities, the prognosis of several
solid tumor malignancies remains poor. Different factors associated with solid tumors …

Natural killer (NK) cells possess potent perforin‐and interferon‐γ‐dependent effector
functions that are tightly regulated. Inhibitory receptors for major histocompatibility complex …