Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem
cells (CSCs), a subset of cells within the tumor with the potential for self-renewal …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Many solid cancers display cellular hierarchies with self-renewing, tumorigenic stemlike
cells, or cancer-initiating cells (CICs) at the apex. Whereas CICs often exhibit relative …

Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including
cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Background Tumor recurrence, the chief reason for poor prognosis of glioma, is largely
attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT) …

Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers
worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic …

BACKGROUND & AIMS: Adult stem cells have been proposed to be quiescent and radiation
resistant, repairing DNA double-strand breaks by nonhomologous end joining. However, the …

Sox2 is known as the undifferentiated cell marker. Recent studies have shown that Sox2
may also be involved in the maintenance of cancer stem cells (CSCs) in skin and bladder …