Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …
tissue and cell functions and significant increases in the risks of various aging-related …
Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
[HTML][HTML] A stem cell aging framework, from mechanisms to interventions
Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …
Decades of scientific research have uncovered processes of stem cell decline in tissue and …
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus
I Matias, LP Diniz, IV Damico, APB Araujo… - Aging cell, 2022 - Wiley Online Library
The increase in senescent cells in tissues, including the brain, is a general feature of normal
aging and age‐related pathologies. Senescent cells exhibit a specific phenotype, which …
aging and age‐related pathologies. Senescent cells exhibit a specific phenotype, which …
The wide and growing range of lamin B-related diseases: from laminopathies to cancer
C Evangelisti, I Rusciano, S Mongiorgi… - Cellular and Molecular …, 2022 - Springer
B-type lamins are fundamental components of the nuclear lamina, a complex structure that
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …
Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian
hippocampus. Advancing age leads to a decline in neurogenesis, which is associated with …
hippocampus. Advancing age leads to a decline in neurogenesis, which is associated with …
Epigenetic aging in adult neurogenesis
Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
Single-nucleus transcriptomic landscape of primate hippocampal aging
The hippocampus plays a crucial role in learning and memory, and its progressive
deterioration with age is functionally linked to a variety of human neurodegenerative …
deterioration with age is functionally linked to a variety of human neurodegenerative …
Lamin B1 as a key modulator of the developing and aging brain
FD Koufi, I Neri, G Ramazzotti, I Rusciano… - Frontiers in Cellular …, 2023 - frontiersin.org
Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear
function and organization. It has been demonstrated that lamin B1 is essential for …
function and organization. It has been demonstrated that lamin B1 is essential for …
[HTML][HTML] Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
A Reilly, JP Creamer, S Stewart, MC Stolla, Y Wang… - Cell stem cell, 2022 - cell.com
Abnormal nuclear morphology is a hallmark of malignant cells widely used in cancer
diagnosis. Pelger-Huët anomaly (PHA) is a common abnormality of neutrophil nuclear …
diagnosis. Pelger-Huët anomaly (PHA) is a common abnormality of neutrophil nuclear …