A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The dmrt1 (doublesex and mab-3 related transcription factor 1) gene is a key regulator of
sex determination and/or gonadal sex differentiation across metazoan animals. This is …

Over the last several decades zebrafish (Danio rerio) has become a major model organism
for the study of vertebrate development and physiology. Given this, it may be surprising how …

The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

A woman's reproductive health and ability to have children directly affect numerous aspects
of her life, from personal well-being and socioeconomic standing, to morbidity and lifespan …

Mammalian sexual development commences when fetal bipotential progenitor cells adopt
male Sertoli (in XY) or female granulosa (in XX) gonadal cell fates. Differentiation of these …

Transcriptional regulators related to the invertebrate sexual regulators doublesex and mab-3
occur throughout metazoans and control sex in most animal groups. Seven of these DMRT …

In vertebrates, sex organs are generally specialized to perform a male or female
reproductive role. Acquisition of the Müllerian duct, which gives rise to the oviduct, together …