Advances in xanthan gum-based systems for the delivery of therapeutic agents

M Jadav, D Pooja, DJ Adams, H Kulhari - Pharmaceutics, 2023 - mdpi.com
In the last three decades, polymers have contributed significantly to the improvement of drug
delivery technologies by enabling the controlled and sustained release of therapeutic …

Polysaccharide-based transdermal drug delivery

J Li, H Xiang, Q Zhang, X Miao - Pharmaceuticals, 2022 - mdpi.com
Materials derived from natural plants and animals have great potential for transdermal drug
delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources …

Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis

MB Zewail, SA El-Gizawy, GF Asaad… - International Journal of …, 2023 - Elsevier
Rheumatoid arthritis (RA), a distressing inflammatory autoimmune disease, is managed
mainly by Disease-modifying antirheumatic drugs (DMARDs), eg leflunomide (LEF). LEF …

Novel formulation of fusidic acid incorporated into a myrrh-oil-based nanoemulgel for the enhancement of skin bacterial infection treatment

MM Almostafa, HS Elsewedy, TM Shehata… - Gels, 2022 - mdpi.com
Fusidic acid (FA) is renowned as an effective bacteriostatic agent obtained from the fungus
Fusidium coccineum, used for treating various eye and skin disorders. The objective of the …

Nanoemulgel as an approach to improve the biopharmaceutical performance of lipophilic drugs: Contemporary research and application

MZ Ahmad, J Ahmad, MY Alasmary, S Akhter… - Journal of Drug Delivery …, 2022 - Elsevier
Abstract The vast majority (≥ 40%) of new drugs developed in drug discovery research or
high-throughput screening are poorly aqueous soluble and lipophilic in nature. This …

A pharmaco-technical investigation of thymoquinone and peat-sourced fulvic acid nanoemulgel: a combination therapy

R Khan, MA Mirza, M Aqil, N Hassan, F Zakir… - Gels, 2022 - mdpi.com
Thymoquinone has a multitude of pharmacological effects and has been researched for a
wide variety of indications, but with limited clinical success. It is associated with pharmaco …

An overview of nanoemulgels for bioavailability enhancement in inflammatory conditions via topical delivery

DK Lal, B Kumar, AS Saeedan, MN Ansari - Pharmaceutics, 2023 - mdpi.com
The anti-inflammatory drugs that are generally available possess the disadvantage of
hydrophobicity, which leads to poor permeability and erratic bioavailability. Nanoemulgels …

Implementation of Quality by Design (QbD) concept for the development of emulsion based nanotailored gel for improved antiphotoageing potential of Silymarin

S Dhawan, S Nanda - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Silymarin is a powerful free radical scavenger, anti-inflammatory and immune system
modulating agent which can be effectively used for the treatment of various skin ailments …

Spanlastics gel-A novel drug carrier for transdermal delivery of glimepiride

EH Elsaied, HM Dawaba, ESA Ibrahim… - Journal of Liposome …, 2023 - Taylor & Francis
Abstract Glimepiride (3rd-generation sulfonylurea) is used for treatment of type 2 diabetes,
but its oral administration has been associated with severe gastric disturbances such as …

Optimization of Potential Nanoemulgels for Boosting Transdermal Glimepiride Delivery and Upgrading Its Anti-Diabetic Activity

MH Abdallah, AS Abu Lila, HM El-Nahas, TM Ibrahim - Gels, 2023 - mdpi.com
Transdermal drug delivery has been widely adopted as a plausible alternative to the oral
route of administration, especially for drugs with poor systemic bioavailability. The objective …