Heart failure (HF) presents a significant clinical challenge, with current treatments mainly
easing symptoms without stopping disease progression. The targeting of calcium (Ca2+) …

Background: Brown adipose tissue (BAT) is an important tissue for thermogenesis, making it
a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular …

The heart either hypertrophies or dilates in response to familial mutations in genes encoding
sarcomeric proteins, which are responsible for contraction and pumping. These mutations …

Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin
complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing …

It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell
retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we …

The cardiac troponin (cTn) complex is an important regulatory protein in heart contraction.
Upon binding of Ca2+, cTn undergoes a conformational shift that allows the troponin I switch …

Control of calcium binding to and dissociation from cardiac troponin C (TnC) is essential to
healthy cardiac muscle contraction/relaxation. There are numerous aberrant post …

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial
arrhythmogenic syndrome characterized by sudden death. There are several genetic forms …

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in
response to Ca 2+. TnC binding Ca 2+ initiates a cascade of protein–protein interactions …

Troponin I (TnI) is a key regulator of cardiac contraction and relaxation with TnI Ser-23/24
phosphorylation serving as a myofilament mechanism to modulate cardiac function. Basal …