Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

Primary human hepatocytes (PHHs) are commonly used for in vitro studies of drug-induced
liver injury. However, when cultured as 2D monolayers, PHH lose crucial hepatic functions …

The liver is one of the largest organs in the body and is responsible for a diverse repertoire
of metabolic processes. Such processes include the secretion of serum proteins …

Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics
and toxicity are essential constituents of preclinical safety assessment pipelines for new …

Idiosyncratic drug‐induced liver injury (DILI) is a rare, often difficult‐to‐predict adverse
reaction with complex pathomechanisms. However, it is now evident that certain forms of …

One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …

Animal testing is still the most popular preclinical assessment model for liver fibrosis. To
develop efficient anti-fibrotic therapies, robust and representative in vitro models are …

Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …

Drug-induced cholestasis (DIC) is poorly understood and its preclinical prediction is mainly
limited to assessing the compound's potential to inhibit the bile salt export pump (BSEP) …