Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of
people worldwide. However recent studies have indicated that niclosamide may have broad …

Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Regulating the tumor microenvironment (TME) has been a promising strategy to improve
antitumor therapy. Here, a red blood cell membrane (mRBC)‐camouflaged hollow MnO2 …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Niclosamide (NIC) has demonstrated promising in vitro antiviral efficacy against SARS-CoV-
2, the causative agent of the COVID-19 pandemic. Though NIC is already FDA-approved …

There is considerable interest in the pH-dependent, switchable, biocatalytic properties of
cerium oxide (CeO2) nanoparticles in biomedicine, where these materials exhibit beneficial …

Quiescent cancer cells in malignant tumors can withstand cell-cycle active treatment and
cause cancer spread and recurrence. Three-dimensional (3D) cancer cell models have led …

Metabolism of cancer cells is characterized by aerobic glycolysis, or the Warburg effect.
Aerobic glycolysis reduces pyruvate flux into mitochondria, preventing a complete oxidation …

The extracellular pH (pHe) is a key determinant of the cellular (micro) environment and
needs to be maintained within strict boundaries to allow normal cell function. Here we used …