The discovery of mouse embryonic stem (ES) cells> 20 years ago represented a major
advance in biology and experimental medicine, as it enabled the routine manipulation of the …

Under appropriate conditions in culture, embryonic stem cells with differentiate and form
embryoid bodies that have been shown to contain cells of the hematopoietic, endothelial …

Hypoxia is an essential developmental and physiological stimulus that plays a key role in
the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality …

Blood cell development relies on the expansion and maintenance of haematopoietic stem
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation
represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex …

The cellular and molecular events regulating the induction and tissue-specific differentiation
of endoderm are central to our understanding of the development and function of many …

The mRNA for the Duffy blood group antigen, the erythrocyte receptor for the Plasmodium
vivax malaria parasite, has recently been cloned and shown to encode a widely expressed …

The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to
mediate cellular uptake of iron from a plasma glycoprotein, transferrin. Iron uptake from …

Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …