Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

The degeneration of light-detecting rod and cone photoreceptors in the human retina leads
to severe visual impairment and ultimately legal blindness in millions of people worldwide …

Innumerable studies associated with cellular differentiation, tissue response and disease
modeling have been conducted in two-dimensional (2D) culture systems or animal models …

Retinal diseases are a rising concern as major causes of blindness in an aging society;
therapeutic options are limited, and the precise pathogenesis of these diseases remains …

Recent advances in stem cell engineering have led to an explosion in the use of organoids
as model systems for studies in multiple biological disciplines. Together with breakthroughs …

Engineered nanomaterials are bestowed with certain inherent physicochemical properties
unlike their parent materials, rendering them suitable for the multifaceted needs of state-of …

Purpose: To expand the use of human retinal organoids from induced pluripotent stem cells
(iPSCs) as an in vitro model of the retina for assessing gene therapy treatments, it is …

Retinal organoids (ROs), which are derived from stem cells, can automatically form three-
dimensional laminar structures that include all cell types and the ultrastructure of the retina …

Early in vivo embryonic retinal development is a well-documented and evolutionary
conserved process. The specification towards eye development is temporally controlled by …

Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …