Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the
gastrointestinal tract, with increasing prevalence, and its pathogenesis remains unclear …

Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

Patients with ulcerative colitis (UC) have a high prevalence of mental disorders, such as
depression and anxiety. Gut microbiota imbalance and disturbed metabolism have been …

Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly
expressed in gut epithelium, contributes to immune responses, and is upregulated during …

The close relationship between primary sclerosing cholangitis (PSC) and inflammatory
bowel disease (IBD) provides a good opportunity to comprehend the gut–liver axis. The gut …

Cholestasis is a condition characterized by the abnormal production or excretion of bile, and
it can be induced by a variety of causes, the factors of which are extremely complex …

Background Biomarker identification is one of the major and important goal of functional
genomics and translational medicine studies. Large scale–omics data are increasingly …

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by
biliary inflammation and stricturing. Exploration of the pathogenesis of PSC in light of its …

Autoimmune liver diseases are a group of immune-mediated liver diseases with three
distinct entities, including autoimmune hepatitis, primary biliary cholangitis, and primary …

Artificial intelligence (AI) is increasingly being utilized in healthcare. This article provides
clinicians and researchers with a step-wise foundation for high-value AI that can be applied …