The secretin-like (class B) family of G protein-coupled receptors (GPCRs) are key players in
hormonal homeostasis and are interesting drug targets for the treatment of several metabolic …

G-protein-coupled receptors (GPCRs) represent the largest constellation of validated drug
targets. Crystal structures of class A GPCRs have facilitated major advances in …

Molecular determinants regulating the activation of class B G-protein-coupled receptors
(GPCRs) by native peptide agonists are largely unknown. We have investigated here the …

The vasoactive intestinal peptide (VIP) is a neuropeptide with wide distribution in both
central and peripheral nervous systems, where it plays important regulatory role in many …

Although family BG protein-coupled receptors (GPCRs) contain only 15 members, they play
key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug …

PTHR1-signaling pathway is critical for the regulation of endochondral ossification. Thus,
abnormalities in genes belonging to this pathway could potentially participate in the …

Despite advances in rheumatoid arthritis (RA) treatment, efficacious and safe disease-
modifying therapy still represents an unmet medical need. Here, we describe an innovative …

It has been 50 years since FH Westheimer and colleagues reported the first use of a
photoactivatable cross-linking reagent to study the active site of chymotrypsin. In studies of …

G protein coupled receptors (GPCRs) play a crucial role in physiology and pathophysiology
in humans. Beside the large family A (rhodopsin-like receptors) and family C GPCR …

Vasoactive intestinal peptide (VIP) is an anti-inflammatory neuropeptide recently identified
as a potential antimicrobial peptide. To overcome the metabolic limitations of VIP, we …