Assembly, structure, function and regulation of type III secretion systems

W Deng, NC Marshall, JL Rowland… - Nature Reviews …, 2017 - nature.com
Type III secretion systems (T3SSs) are protein transport nanomachines that are found in
Gram-negative bacterial pathogens and symbionts. Resembling molecular syringes, T3SSs …

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells

JE Galán, M Lara-Tejero, TC Marlovits… - Annual review of …, 2014 - annualreviews.org
One of the most exciting developments in the field of bacterial pathogenesis in recent years
is the discovery that many pathogens utilize complex nanomachines to deliver bacterially …

Type three secretion system in attaching and effacing pathogens

MO Gaytán, VI Martínez-Santos, E Soto… - Frontiers in cellular …, 2016 - frontiersin.org
Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic
bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes …

Atomic model of the type III secretion system needle

A Loquet, NG Sgourakis, R Gupta, K Giller, D Riedel… - Nature, 2012 - nature.com
Pathogenic bacteria using a type III secretion system (T3SS), to manipulate host cells cause
many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic …

Type III secretion: building and operating a remarkable nanomachine

AG Portaliou, KC Tsolis, MS Loos, V Zorzini… - Trends in biochemical …, 2016 - cell.com
The Type III secretion system (T3SS) is a protein export pathway that is widespread in Gram-
negative bacteria and delivers effector proteins directly into eukaryotic cells. At its core lie …

Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

J Hu, LJ Worrall, C Hong, M Vuckovic… - Nature …, 2018 - nature.com
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …

Structure of a pathogenic type 3 secretion system in action

J Radics, L Königsmaier, TC Marlovits - Nature structural & molecular …, 2014 - nature.com
Abstract Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded'
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …

Assembly of the bacterial type III secretion machinery

A Diepold, S Wagner - FEMS microbiology reviews, 2014 - academic.oup.com
Many bacteria that live in contact with eukaryotic hosts, whether as symbionts or as
pathogens, have evolved mechanisms that manipulate host cell behaviour to their benefit …

[HTML][HTML] Assembly and structure of the T3SS

BJ Burkinshaw, NCJ Strynadka - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Abstract The Type III Secretion System (T3SS) is a multi-mega Dalton apparatus assembled
from more than twenty components and is found in many species of animal and plant …

The structure and function of type III secretion systems

RQ Notti, CE Stebbins - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
Type III secretion systems (T3SSs) afford Gram‐negative bacteria an intimate means of
altering the biology of their eukaryotic hosts—the direct delivery of effector proteins from the …