Tratamento da leishmaniose, limitações da terapêutica atual ea necessidade de novas alternativas: Uma revisão narrativa

AS Santiago, SS da Rocha Pita… - Research, Society and …, 2021 - rsdjournal.org
Leishmaniasis groups some neglected diseases caused by intracellular protozoa
Leishmania. Its main clinical forms are the tegumentary (LT) and Visceral (LV). Currently, the …

Targeting Leishmania Promastigotes and Amastigotes Forms through Amino Acids and Peptides: A Promising Therapeutic Strategy

C Registre, LM Silva, F Registre… - ACS Infectious …, 2024 - ACS Publications
Millions of people worldwide are affected by leishmaniasis, caused by the Leishmania
parasite. Effective treatment is challenging due to the biological complexity of the parasite …

Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez.(Lauraceae Juss.)

PM Andrade, DC Melo, AET Alcoba… - Anais da Academia …, 2018 - SciELO Brasil
Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which
affects around two million people worldwide. One major drawback in the treatment of …

Essential oils from Protium heptaphyllum fresh young and adult leaves (Burseraceae): chemical composition, in vitro leishmanicidal and cytotoxic effects

RSC Cabral, CC Fernandes, ALB Dias… - Journal of Essential …, 2021 - Taylor & Francis
In this study, the chemical composition and in vitro antileishmanial activity of essential oils
(EOs) from Protium heptaphyllum fresh young (PY-EO) and adult (PA-EO) leaves against …

Microemulsion based on methyl 3,4,5-trihydroxybenzoate for the topical treatment of cutaneous leishmaniasis: an in vivo assay

TJ BACHA, BB JENSEN, DC RODRIGUES… - Acta …, 2023 - SciELO Brasil
Cutaneous leishmaniasis, caused by protozoa of the genus Leishmania, presents diverse
clinical manifestations, and current therapeutic options have limitations, including long …

[引用][C] Evaluation of the in vivo and in vitro effect of Libidibia ferrea on Leishmania (Leishmania) amazonensis

TDJ Bacha, BB Jensen, AS de Jesus, PET Iwabuchi… - Peer W, 2023 - peerw.org
Currently, the therapeutic arsenal available for the treatment of leishmaniasis is limited.
Thus, the aim of this study was to evaluate the in vitro and in vivo antileishmanial efficacy of …

In vitro and in vivo activity of a hypotoxic copper(I) complex against dermotropic Leishmania species

AFS Chagas, M Porchia, TP Nascimento… - Acta …, 2021 - SciELO Brasil
Cutaneous leishmaniasis is a disease caused by protozoa of the genus Leishmania and,
currently, the treatment of first choice is meglumine antimoniate. However, due to its limited …

In vitro evaluation of antileishmanial activity of copper (I) complexes

AF da Silva Chagas, M Porchia, F Tisato… - Acta …, 2021 - revistas.ufcg.edu.br
In the research for the development of new drugs for the therapy of American tegumentary
leishmaniasis, copper has been studied for its antileishmania activity. This study aims to …

[PDF][PDF] Desafios e perspectivas no tratamento da leishmaniose tegumentar: revisão de literatura

VN Holanda, WV da Silva… - … : saúde, humanas e …, 2018 - researchgate.net
As leishmanioses são doenças prevalentes e negligenciadas que afetam à saúde pública e
estão cada vez mais presentes nos países em desenvolvimento. A ampla distribuição dos …

[PDF][PDF] Antileishmanial Activity of Itraconazole (Sporanox®) and Fluconazole (Zoltec®) on Leishmania spp.: In Silico and In Vitro Studies for Repurposing Drugs

RP dos SANTOS, BB JENSEN, RSB HANADA… - Lat. Am. J …, 2024 - researchgate.net
Neglected Tropical Diseases (NTDs) are prevalent in tropical regions with high social
vulnerability. The Brazilian government has established a research and development …