The Klotho proteins in health and disease

M Kuro-o - Nature Reviews Nephrology, 2019 - nature.com
Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

[HTML][HTML] Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

ER De Kloet, OC Meijer, AF de Nicola… - Frontiers in …, 2018 - Elsevier
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …

Mechanisms involved in the side effects of glucocorticoids

H Schäcke, WD Döcke, K Asadullah - Pharmacology & therapeutics, 2002 - Elsevier
Glucocorticoids (GCs) represent the most important and frequently used class of anti-
inflammatory drugs. While the therapeutic effects of GCs have been known and used for …

Regulation of the renal NaCl cotransporter and its role in potassium homeostasis

EJ Hoorn, M Gritter, CA Cuevas… - Physiological …, 2020 - journals.physiology.org
Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

FGF 23 regulates renal sodium handling and blood pressure

O Andrukhova, S Slavic, A Smorodchenko… - EMBO molecular …, 2014 - embopress.org
Abstract Fibroblast growth factor‐23 (FGF 23) is a bone‐derived hormone regulating renal
phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show …

Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure

S Kellenberger, L Schild - Physiological reviews, 2002 - journals.physiology.org
The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family
encodes sodium channels involved in various cell functions in metazoans. Subfamilies …

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

A Brunet, J Park, H Tran, LS Hu… - … and cellular biology, 2001 - Am Soc Microbiol
Serum-and glucocorticoid-inducible kinases (SGKs) form a novel family of serine/threonine
kinases that are activated in response to a variety of extracellular stimuli. SGKs are related to …

Adrenal cortex

PM Stewart - Current Opinion in Endocrinology, Diabetes and …, 1999 - journals.lww.com
Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress

N Pecoraro, F Reyes, F Gomez, A Bhargava… - …, 2004 - academic.oup.com
We suggested a new model of the effects of glucocorticoids (GCs) exerted during chronic
stress, in which GCs directly stimulate activities in the brain while indirectly inhibiting activity …

Electrolyte transport in the mammalian colon: mechanisms and implications for disease

K Kunzelmann, M Mall - Physiological reviews, 2002 - journals.physiology.org
The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …