Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Mechanisms of mesenchymal stem/stromal cell function

JL Spees, RH Lee, CA Gregory - Stem cell research & therapy, 2016 - Springer
The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

MSC exosome works through a protein-based mechanism of action

WS Toh, RC Lai, B Zhang, SK Lim - Biochemical Society …, 2018 - portlandpress.com
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

Mesenchymal stem cell exosomes

RC Lai, RWY Yeo, SK Lim - Seminars in cell & developmental biology, 2015 - Elsevier
MSCs are an extensively used cell type in clinical trials today. The initial rationale for their
clinical testing was based on their differentiation potential. However, the lack of correlation …

Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery

RWY Yeo, RC Lai, B Zhang, SS Tan, Y Yin… - Advanced drug delivery …, 2013 - Elsevier
Advances in biomedical research have generated an unprecedented number of potential
targets for therapeutic intervention to treat disease or delay disease progression …

Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells

M Strioga, S Viswanathan, A Darinskas… - Stem cells and …, 2012 - liebertpub.com
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with
multilineage differentiation potential, the ability to modulate oxidative stress, and secrete …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Role of human mesenchymal stem cells in regenerative therapy

J Vasanthan, N Gurusamy, S Rajasingh, V Sigamani… - Cells, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent cells which can proliferate and replace
dead cells in the body. MSCs also secrete immunomodulatory molecules, creating a …

Exosomes for drug delivery—a novel application for the mesenchymal stem cell

RC Lai, RWY Yeo, KH Tan, SK Lim - Biotechnology advances, 2013 - Elsevier
Exosomes are the most extensively characterized class of secreted membrane vesicles that
carry proteins and RNAs for intercellular communication. They are increasingly seen as …

A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial …

JM Hare, JH Traverse, TD Henry, N Dib… - Journal of the American …, 2009 - jacc.org
Objectives: Our aim was to investigate the safety and efficacy of intravenous allogeneic
human mesenchymal stem cells (hMSCs) in patients with myocardial infarction (MI) …