Zebrafish as a model for drug induced liver injury: state of the art and beyond
G Cakan-Akdogan, AM Aftab, MC Cinar… - Exploration of …, 2023 - explorationpub.com
Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple
advantages ranging from ease of breeding and maintenance, availability of different strains …
advantages ranging from ease of breeding and maintenance, availability of different strains …
Transgenic zebrafish expressing rat cytochrome P450 2E1 (CYP2E1): augmentation of Acetaminophen-Induced toxicity in the liver and Retina
Y Sato, W Dong, T Nakamura, N Mizoguchi… - International Journal of …, 2023 - mdpi.com
Metabolic activation is the primary cause of chemical toxicity including hepatotoxicity.
Cytochrome P450 2E (CYP2E) is involved in this process for many hepatotoxicants …
Cytochrome P450 2E (CYP2E) is involved in this process for many hepatotoxicants …
The developmental stage is a critical parameter for accurate assessment of the drug-induced liver injury (DILI) potentials of drugs with the zebrafish larval liver model
GÇ Akdoğan, Ç Bilgi - Biotech Studies - dergipark.org.tr
Prediction of drug-induced liver injury (DILI) potential of drugs is one of the most challenging
issues of drug development. Zebrafish larvae provide an in vivo and robust test platform …
issues of drug development. Zebrafish larvae provide an in vivo and robust test platform …