Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon.

SL De Sousa, R Dickinson, WR Lieb, NP Franks - Anesthesiology, 2000 - europepmc.org
Background The mechanisms by which the inhalational general anesthetics isoflurane and
xenon exert their effects are unknown. Moreover, there have been surprisingly few …

Physiological evidence for two distinct GABAA responses in rat hippocampus

RA Pearce - Neuron, 1993 - cell.com
The y-aminobutyric acidA (GABAJ receptor is a ligandgated ionophore involved in synaptic
inhibition. Biochemical and molecular biological studies indicate that considerable receptor …

Awareness in anaesthesia: Incidence, consequences and prevention.

T Heier, PA Steen - Acta Anaesthesiologica Scandinavica, 1996 - europepmc.org
Awareness during anaesthesia is a state of consciousness that is revealed by explicit or
implicit memory of intraoperative events. Although large clinical surveys indicate an …

Enhancement of gamma‐aminobutyric acid‐activated Cl‐currents in cultured rat hippocampal neurones by three volatile anaesthetics.

MV Jones, PA Brooks, NL Harrison - The Journal of physiology, 1992 - Wiley Online Library
1. The effects of the volatile anaesthetics enflurane, halothane and isoflurane on gamma‐
aminobutyric acid (GABA) A receptor‐mediated chloride currents were studied in cultured rat …

[HTML][HTML] Do inhalational anesthetics cause cognitive dysfunction?

R Ologunde, D Ma - Acta Anaesthesiologica Taiwanica, 2011 - Elsevier
Increasing evidence indicates that inhalational anesthetics may cause or increase the risk of
developing postoperative cognitive dysfunction (POCD), especially in the elderly population …

Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics

MW Hollmann, HT Liu, CW Hoenemann… - Anesthesia & …, 2001 - journals.lww.com
IMPLICATIONS: Clinically relevant concentrations of volatile anesthetics inhibit functioning
of N-methyl-d-aspartate receptors expressed recombinantly in Xenopus oocytes. This …

Volatile anesthetics depress glutamate transmission via presynaptic actions.

MB Maclver, AA Mikulec, SM Amagasu… - Anesthesiology, 1996 - europepmc.org
Background Recent evidence for a presynaptic depression of glutamate release produced
by volatile anesthetics prompted the current study of isoflurane and halothane effects on …

Isoflurane blocks synaptic plasticity in the mouse hippocampus.

W Simon, G Hapfelmeier, E Kochs… - …, 2001 - europepmc.org
Background The volatile anesthetic isoflurane depresses glutamatergic transmission. In this
study, the authors investigated the effects of isoflurane on the induction of long-term …

Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine

G Zhang, Y Dong, B Zhang, F Ichinose… - Journal of …, 2008 - Soc Neuroscience
Increasing evidence indicates that caspase activation and apoptosis are associated with a
variety of neurodegenerative disorders, including Alzheimer's disease. We reported that …

GABAA Receptor α5 Subunits Contribute to GABAA,slow Synaptic Inhibition in Mouse Hippocampus

ED Zarnowska, R Keist, U Rudolph… - Journal of …, 2009 - journals.physiology.org
γ-Aminobutyric acid type A (GABAA) receptor α5 subunits, which are heavily expressed in
the hippocampus, are potential drug targets for improving cognitive function. They are found …