The y-aminobutyric acidA (GABAJ receptor is a ligandgated ionophore involved in synaptic inhibition. Biochemical and molecular biological studies indicate that considerable receptor …
T Heier, PA Steen - Acta Anaesthesiologica Scandinavica, 1996 - europepmc.org
Awareness during anaesthesia is a state of consciousness that is revealed by explicit or implicit memory of intraoperative events. Although large clinical surveys indicate an …
MV Jones, PA Brooks, NL Harrison - The Journal of physiology, 1992 - Wiley Online Library
1. The effects of the volatile anaesthetics enflurane, halothane and isoflurane on gamma‐ aminobutyric acid (GABA) A receptor‐mediated chloride currents were studied in cultured rat …
R Ologunde, D Ma - Acta Anaesthesiologica Taiwanica, 2011 - Elsevier
Increasing evidence indicates that inhalational anesthetics may cause or increase the risk of developing postoperative cognitive dysfunction (POCD), especially in the elderly population …
IMPLICATIONS: Clinically relevant concentrations of volatile anesthetics inhibit functioning of N-methyl-d-aspartate receptors expressed recombinantly in Xenopus oocytes. This …
MB Maclver, AA Mikulec, SM Amagasu… - Anesthesiology, 1996 - europepmc.org
Background Recent evidence for a presynaptic depression of glutamate release produced by volatile anesthetics prompted the current study of isoflurane and halothane effects on …
W Simon, G Hapfelmeier, E Kochs… - …, 2001 - europepmc.org
Background The volatile anesthetic isoflurane depresses glutamatergic transmission. In this study, the authors investigated the effects of isoflurane on the induction of long-term …
G Zhang, Y Dong, B Zhang, F Ichinose… - Journal of …, 2008 - Soc Neuroscience
Increasing evidence indicates that caspase activation and apoptosis are associated with a variety of neurodegenerative disorders, including Alzheimer's disease. We reported that …
ED Zarnowska, R Keist, U Rudolph… - Journal of …, 2009 - journals.physiology.org
γ-Aminobutyric acid type A (GABAA) receptor α5 subunits, which are heavily expressed in the hippocampus, are potential drug targets for improving cognitive function. They are found …