Synaptic activity imposes large energy demands that are met by local adenosine
triphosphate (ATP) synthesis through glycolysis and mitochondrial oxidative …

Mitochondria have a number of essential roles in neuronal function. Their complex mobility
patterns within neurons are characterized by frequent changes in direction. Mobile …

Stroke is the leading cause of death and adult disability worldwide. Mitochondrial
dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) …

Vigorous transport of cytoplasmic components along axons over substantial distances is
crucial for the maintenance of neuron structure and function. The transport of mitochondria …

Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons
use specialized mechanisms to drive mitochondria transport and to anchor them in axons …

Mitochondrial electron transport generates the ATP that is essential for the excitability and
survival of neurons, and the protein phosphorylation reactions that mediate synaptic …

Long-distance intracellular delivery is driven by kinesin and dynein motor proteins that ferry
cargoes along microtubule tracks [1, 2]. Current models postulate that directional trafficking …

Organelle transport is vital for the development and maintenance of axons, in which the
distances between sites of organelle biogenesis, function, and recycling or degradation can …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

To address questions about mechanisms of filament-based organelle transport, a system
was developed to image and track mitochondria in an intact Drosophila nervous system …