Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

[HTML][HTML] Cancer stem cells in oral cavity squamous cell carcinoma: a review

R Baillie, ST Tan, T Itinteang - Frontiers in Oncology, 2017 - frontiersin.org
Cancer stem cells (CSCs) have been identified in oral cavity squamous cell carcinoma
(OCSCC). CSCs possess the ability for perpetual self-renewal and proliferation, producing …

Curcumin suppresses lung cancer stem cells via inhibiting Wnt/β‐catenin and sonic hedgehog pathways

JY Zhu, X Yang, Y Chen, YE Jiang… - Phytotherapy …, 2017 - Wiley Online Library
Cancer stem cells (CSCs) are highly implicated in the progression of human cancers. Thus,
targeting CSCs may be a promising strategy for cancer therapy. Wnt/β‐catenin and Sonic …

Cancer stem cells in head and neck squamous cell carcinoma: identification, characterization and clinical implications

C Peitzsch, J Nathansen, SI Schniewind, F Schwarz… - Cancers, 2019 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed
cancer worldwide. Despite advances in the treatment management, locally advanced …

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

P Su, Y Yang, G Wang, X Chen… - … journal of oncology, 2018 - spandidos-publications.com
Resistance to conventional chemotherapeutic agents, including irinotecan (CPT‑11), 5-
fluorouracil and capecitabine is a major cause for therapeutic failure in patients with …

[HTML][HTML] Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral …

F Geng, J Liu, Y Guo, C Li, H Wang, H Wang… - Frontiers in cellular …, 2017 - frontiersin.org
Recent epidemiological studies revealed a significant association between oral squamous
cell carcinoma (OSCC) and Porphyromonas gingivalis, a major pathogen of periodontal …

Nicotinamide N‐methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines

R Campagna, E Salvolini, V Pompei… - Pigment Cell & …, 2021 - Wiley Online Library
Melanoma accounts for less than 5% of all cutaneous neoplasms but is responsible for the
greater part of skin cancer–related deaths. Therefore, the identification of molecules that …

Wnt/β-catenin pathway mediates (−)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells

J Zhu, Y Jiang, X Yang, S Wang, C Xie, X Li, Y Li… - Biochemical and …, 2017 - Elsevier
Cancer stem cells (CSCs) play essential role in the progression of many tumors. Wnt/β-
catenin pathway is crucial in maintaining the stemness of CSCs.(−)-Epigallocatechin-3 …

Nicotinamide N-Methyltransferase as Promising Tool for Management of Gastrointestinal Neoplasms

V Pozzi, R Campagna, D Sartini, M Emanuelli - Biomolecules, 2022 - mdpi.com
Gastrointestinal (GI) neoplasms include esophageal, gastric, colorectal, hepatic, and
pancreatic cancers. They are characterized by asymptomatic behavior, being responsible for …

LncRNA WDFY3-AS2 promotes cisplatin resistance and the cancer stem cell in ovarian cancer by regulating hsa-miR-139-5p/SDC4 axis

Y Wu, T Wang, L Xia, M Zhang - Cancer Cell International, 2021 - Springer
Background Ovarian cancer (OC) is a high-mortality gynecological cancer that is typically
treated with cisplatin, although such treatment often results in chemoresistance. Ovarian …