Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia

DE Surate Solaligue… - … of Physiology-Lung …, 2017 - journals.physiology.org
The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Phenotypes of bronchopulmonary dysplasia

SH Wang, PN Tsao - International Journal of Molecular Sciences, 2020 - mdpi.com
Bronchopulmonary dysplasia (BPD) is the most common chronic morbidity in preterm
infants. In the absence of effective interventions, BPD is currently a major therapeutic …

The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

Recent advances in the pathogenesis of BPD

RE Morty - Seminars in perinatology, 2018 - Elsevier
Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications
of preterm birth and is characterized histopathologically by impaired lung alveolarization …

Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants

JC Lao, CB Bui, MA Pang, SX Cho, I Rudloff… - Science translational …, 2022 - science.org
Postnatal maturation of the immune system is poorly understood, as is its impact on illnesses
afflicting term or preterm infants, such as bronchopulmonary dysplasia (BPD) and BPD …

Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases

M Lam, E Lamanna, L Organ, C Donovan… - Frontiers in …, 2023 - frontiersin.org
Precision cut lung slices (PCLS) have emerged as powerful experimental tools for
respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary …

Pharmacotherapy in bronchopulmonary dysplasia: what is the evidence?

RP Sakaria, R Dhanireddy - Frontiers in Pediatrics, 2022 - frontiersin.org
Bronchopulmonary Dysplasia (BPD) is a multifactorial disease affecting over 35% of
extremely preterm infants born each year. Despite the advances made in understanding the …

[HTML][HTML] Pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants

CB Bui, MA Pang, A Sehgal, C Theda, JC Lao… - Journal of reproductive …, 2017 - Elsevier
Bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension (BPD-
PH) are chronic inflammatory cardiopulmonary diseases with devastating short-and long …

Generation of human 3D lung tissue cultures (3D-LTCs) for disease modeling

M Gerckens, HN Alsafadi, DE Wagner… - JoVE (Journal of …, 2019 - jove.com
Translation of novel discoveries to human disease is limited by the availability of human
tissue-based models of disease. Precision-cut lung slices (PCLS) used as 3D lung tissue …

Another one fights the dust: targeting the NLRP3 inflammasome for the treatment of silicosis

M Lam, A Mansell, MD Tate - American journal of respiratory cell …, 2022 - atsjournals.org
Silicosis is a multifaceted lung disease, characterized by persistent inflammation and
structural remodeling. Despite its poor prognosis, there are no treatments currently available …