How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?
Y Geng, KN Faber, VE de Meijer, H Blokzijl… - Hepatology …, 2021 - Springer
Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …
accumulation in the liver which is not due to alcohol use, has emerged as one of the major …
Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis
H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …
representing the most common chronic liver disease in the world. Atherosclerotic …
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Y Yang, P Sangwung, R Kondo, Y Jung… - Journal of …, 2021 - Elsevier
Background & Aims Liver sinusoidal endothelial cell (LSEC) dysfunction has been reported
in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus …
in alcohol-related liver disease, yet it is not known whether LSECs metabolize alcohol. Thus …
Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis
Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage.
Hyperlipidemic LDL-R-–deficient mice transgenic for an OxPC-recognizing IgM fragment …
Hyperlipidemic LDL-R-–deficient mice transgenic for an OxPC-recognizing IgM fragment …
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
X Jiang, Y Li, D Fu, T You, S Wu, J Xin, J Wen… - International …, 2023 - Elsevier
The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients
with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator …
with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator …
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease
GH Deng, CF Wu, YJ Li, H Shi, WC Zhong… - Military Medical …, 2023 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and
iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) …
iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) …
Caveolin-1 protects against liver damage exacerbated by acetaminophen in non-alcoholic fatty liver disease by inhibiting the ERK/HIF-1α pathway
T You, Y Li, B Li, S Wu, X Jiang, D Fu, J Xin… - Molecular …, 2023 - Elsevier
Acetaminophen (APAP) is a common antipyretic and analgesic drug that can cause long-
term liver damage after an overdose. Non-alcoholic fatty liver disease (NAFLD) increases …
term liver damage after an overdose. Non-alcoholic fatty liver disease (NAFLD) increases …
[HTML][HTML] Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese
X Jia, E Song, Y Liu, J Chen, P Wan, Y Hu, D Ye… - Cell Reports …, 2023 - cell.com
The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive
and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein …
and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein …
Synapsin-promoted caveolin-1 overexpression maintains mitochondrial morphology and function in PSAPP Alzheimer's disease mice
Mitochondrial dysfunction plays a pivotal role in the Alzheimer's Disease (AD) pathology.
Disrupted mitochondrial dynamics (ie, fusion/fission balance), which are essential for normal …
Disrupted mitochondrial dynamics (ie, fusion/fission balance), which are essential for normal …
Caveolin-1 ameliorates hepatic injury in non-alcoholic fatty liver disease by inhibiting ferroptosis via the NOX4/ROS/GPX4 pathway
S Wu, N Guo, H Xu, Y Li, T Sun, X Jiang, D Fu… - Biochemical …, 2024 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease globally,
with a complex and contentious pathogenesis. Caveolin-1 (CAV1) is an important regulator …
with a complex and contentious pathogenesis. Caveolin-1 (CAV1) is an important regulator …